Origen, morfología y significancia clínica de microvesículas de tumor en cáncer gástrico

Marina Alekseevna Senchukova

doi:10.54502/msuceva.v2n1a2

Autores/as

Marina Alekseevna Senchukova Department of Oncology, Orenburg State Medical University, Orenburg 460021, Russia https://orcid.org/0000-0001-8371-740X

DOI:

https://doi.org/10.54502/msuceva.v2n1a2

Palabras clave:

Angiogénesis, Cáncer gástrico, endotelial vascular, factor de crecimiento, hipoxia, microvasos tumorales, pronóstico

Resumen

El cáncer gástrico (CG) continúa siendo un grave problema oncológico, ocupando el tercer lugar en la estructura de mortalidad por neoplasias malignas. Mejorar los resultados del tratamiento para esta patología, depende en gran medida, de la comprensión de la patogenia y de las características biológicas del CG; incluida la identificación y caracterización de los biomarcadores de diagnóstico, pronóstico, predicción y biomarcadores terapéuticos. Se conoce que la principal causa de muerte por neoplasias malignas y CG, en particular, es la metástasis tumoral. Dado que la angiogénesis es un proceso crítico para el crecimiento tumoral y la metástasis, ahora se considera un marcador importante del pronóstico de la enfermedad y la sensibilidad a la terapia contra el cáncer. En la revisión presentada, se consideran los conceptos modernos de los mecanismos de formación de vasos tumorales y las peculiaridades de su morfología; se resumen datos sobre numerosos factores que influyen en la formación de microvasos tumorales y su papel en la progresión de GC; y se destacan varios enfoques para la clasificación de los vasos tumorales, así como los métodos para evaluar la actividad de la angiogénesis en un tumor. Aquí, también se discuten los resultados de los estudios sobre el significado pronóstico y predictivo de los microvasos tumorales en GC, y se propone para su consideración, una nueva clasificación de microvasos tumorales en GC, basada en su morfología y significado clínico.

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Biografía del autor/a

Marina Alekseevna Senchukova, Department of Oncology, Orenburg State Medical University, Orenburg 460021, Russia

PhD, Profesora Asociada del Departamento de Oncología, Orenburg State Medical University Orenburg 460021, Rusia. Actualmente es editora de la Revista World Journal of Gastrointestinal Oncology (Q2) https://www.wjgnet.com/1948-5204/MemberDetail/513005

Ha publicado más de 30 artículos como autora principal y 100 artículos como coautora en revistas científicas internacionales de renombre y además, posee seis patentes de invención de la Federación Rusa. Sus intereses de investigación incluyen: mecanismos de angiogénesis tumoral, transformación epitelio-mesenquimatosa y el papel de la inflamación en la progresión tumoral.

Citas

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